If you're moving into a totally different niche (e.g., fitness → finance), it's smarter to create a new pixel. Meta’s pixel learns based on user behavior and past conversions, so reusing a pixel trained on a different audience could send mixed signals to the algorithm—making it harder to optimize effectively for your new campaign.
However, if your new niche is somewhat related (e.g., men's fashion → grooming products), the existing pixel might still be helpful due to overlapping buyer behaviors. In that case, you can test using the current pixel but monitor performance closely.
For clean optimization and better tracking, it's generally best to separate pixels by niche or business model, especially if you're scaling or running long-term ads.